研究成果Achievements

2024年

     *equal contribution  #corresponding author

  1. Obox4 promotes zygotic genome activation upon loss of Dux
    *Guo Y, *Kitano T, *Inoue K, Murano K, M Hirose K, Li TD, Sakashita A, Ishizu H, Ogonuki N, Matoba S​​​​​​, Sato M, #Ogura A, #Siomi H
    Elife. 2024 Jun 24:13:e95856. doi: 10.7554/eLife.95856.

  2. H3.1/3.2 regulate the initial progression of the gene expression program
    #Funaya S, Takahashi Y, Suzuki MG, Suzuki Y, #Aoki F.
    Nucleic Acids Res. 2024 Jun 24;52(11):6158-6170. doi: 10.1093/nar/gkae214.
    紹介記事

  3. Reduction of H3K9 methylation by G9a inhibitors improves the development of mouse SCNT embryos
    Matoba S, Shikata D, Shirai F, Tatebe T, Hirose M, Nakata A, Watanabe N, Hasegawa A, Ito A, Yoshida M, #Ogura A.
    Stem Cell Reports. 2024 Jun 11;19(6):906-921. doi: 10.1016/j.stemcr.2024.04.003. Epub 2024 May 9.

  4. Development of a chemically disclosed serum-free medium for mouse pluripotent stem cells
    Tomoka Katayama,  Marina Takechi, Yamato Murata, Yuta Chigi,  #Shinpei Yamaguchi, #Daiji Okamura
    Front Bioeng Biotechnol. 2024 May 15:12:1390386. doi: 10.3389/fbioe.2024.1390386. eCollection 2024.

  5. Precise immunofluorescence canceling for highly multiplexed imaging to capture specific cell states
    *Tomimatsu K,  *Fujii T, Bise R, Hosoda K, Taniguchi Y, Ochiai H, Ohishi H, Ando K, Minami R, Tanaka K, ​​​​​​ T Tachibana , S Mori , A Harada , K Maehara , M Nagasaki , S Uchida , H Kimura , Narita M, #Ohkawa Y.
    Nat Commun. 2024 May 8;15(1):3657. doi: 10.1038/s41467-024-47989-9.

  6. H3K4me1 facilitates promoter-enhancer interactions and gene activation during embryonic stem cell differentiation
    #Kubo N, Chen PB, Hu R, Ye Z, Sasaki H, #Ren B.
    Mol Cell. 2024 May 2;84(9):1742-1752.e5. doi: 10.1016/j.molcel.2024.02.030. Epub 2024 Mar 20.

  7. Detection of newly synthesized RNA reveals transcriptional reprogramming during ZGA and a role of Obox3 in totipotency acquisition
    Sakamoto M, Ito A, Wakayama S, Sasaki H , Wakayama T, #Ishiuchi T.
    Cell Rep. 2024 Apr 23;43(4):114118. doi: 10.1016/j.celrep.2024.114118. Epub 2024 Apr 14.

  8. Combined and differential roles of ADD domains of DNMT3A and DNMT3L on DNA methylation landscapes in mouse germ cells
    #Kubo N, Uehara R, Uemura S, Ohishi H, Shirane K, #Sasaki H.
    Nat Commun. 2024 Apr 16;15(1):3266. doi: 10.1038/s41467-024-47699-2.
    紹介記事

  9. Detection of newly synthesized RNA reveals transcriptional reprogramming during ZGA and a role of Obox3 in totipotency acquisition
    Sakamoto M, Ito A, Wakayama S, Sasaki H, Wakayama T, #Ishiuchi T.
    Cell Rep. 2024 Apr 14;43(4):114118. doi: 10.1016/j.celrep.2024.114118. Online ahead of print.
    紹介記事

  10. DPPA3 facilitates genome-wide DNA demethylation in mouse primordial germ cells
    Toriyama K, Au Yeung W, Inoue A, Kurimoto K, Yabuta Y, Saitou M, #Nakamura T, Nakano T, Sasaki H.
    BMC Genomics. 2024 Apr 5;25(1):344. doi: 10.1186/s12864-024-10192-7.

  11. Production of a Monoclonal Antibody for Histone H2b Isoform H2b3b.
    Egashira S, Tachibana T, Nakamura M, Ohkawa Y, Harada A.
    Monoclon Antib Immunodiagn Immunother. 2024 Apr;43(2):75-80. doi: 10.1089/mab.2023.0025. Epub 2024 Mar 19.

  12. Recombinant cyclin B-Cdk1-Suc1 capable of multi-site mitotic phosphorylation in vitro
    #Shintomi K, Masahara-Negishi Y, Shima M, Tane S, Hirano T
    PLoS One. 2024 Mar 25;19(3):e0299003. doi: 10.1371/journal.pone.0299003. eCollection 2024.

  13. H3K4me1 facilitates promoter-enhancer interactions and gene activation during embryonic stem cell differentiation
    #Kubo N, Chen PB, Hu R, Ye Z, Sasaki H, #Ren B.
    Molecular Cell March 20, 2024; doi.org/10.1016/j.molcel.2024.02.030
    紹介記事

  14. The fluid factor OVGP1 provides a significant oviductal microenvironment for the reproductive process in golden hamster.
    Yamatoya K, Kurosawa M, Hirose M, Miura Y, Taka H, Nakano T, Hasegawa A, Kagami K, Yoshitake H, Goto K, Ueno T, Fujiwara H, Shinkai Y, Kan FWK, Ogura A, #Araki Y.
    Biol Reprod. 2024 Mar 13;110(3):465-475. doi: 10.1093/biolre/ioad159. Erratum in: Biol Reprod. 2024 Jan 15

  15. Tex46 knockout male mice are sterile secondary to sperm head malformations and failure to penetrate through the zona pellucida
    #Fujihara Y, Miyata H, Abbasi F, Larasati T, Nozawa K, Yu Z,  Ikawa M, Matzuk MM.
    PNAS Nexus. 2024 Mar 12;3(3):pgae108. doi: 10.1093/pnasnexus/pgae108. eCollection 2024 Mar.

  16. Modeling embryo-endometrial interface recapitulating human embryo implantation. 
    #Shibata S, Endo S, Nagai LAE, H Kobayashi E, Oike A, Kobayashi N, Kitamura A, Hori T, Nashimoto Y, Nakato R, Hamada H, Kaji H, Kikutake C, Suyama M, Saito M, Yaegashi N, Okae H, #Arima T.
    Sci Adv. 2024 Feb 23;10(8):eadi4819. doi: 10.1126/sciadv.adi4819. Epub 2024 Feb 23.

  17. PABPN1L is required for maternal mRNA degradation after meiosis resumption
    Emori C, Kodani M, Abbasi F, Mori M, #Ikawa M.
    J Reprod Dev. 2024 Feb 19;70(1):10-17. doi: 10.1262/jrd.2023-077. Epub 2023 Dec 7.

  18. Disruption of testis-enriched cytochrome c oxidase subunit COX6B2 but not COX8C leads to subfertility
    #Shimada K, Lu Y, #Ikawa M.
    Exp Anim. 2024 Feb 14;73(1):1-10. doi: 10.1538/expanim.23-0055. Epub 2023 Jul 10.

  19. YY1-dependent transcriptional regulation manifests at the morula stage
    Sakamoto M, #Ishiuchi T. 
    MicroPubl Biol. 2024 Jan 16:2024:10.17912/micropub.biology.001108. doi: 10.17912/micropub.biology.001108. eCollection 2024.

  20. Multiple ageing effects on testicular/epididymal germ cells lead to decreased male fertility in mice
    #Endo T, Kobayashi K, Matsumura T, Emori C, Ozawa M, Kawamoto S, Okuzaki D, Shimada K, Miyata H, Shimada K, Kodani M, Ishikawa-Yamauchi Y, Motooka D, Hara E, #Ikawa M.
    Commun Biol. 2024 Jan 4;7(1):16. doi: 10.1038/s42003-023-05685-2.

 *equal contribution  #corresponding author

  1. Nuclear actin dynamics and functions at a glance.
    Ulferts S, Lopes M, Miyamoto K, #Grosse R.
    J Cell Sci. 2024 Mar 15;137(6):jcs261630. doi: 10.1242/jcs.261630. Epub 2024 Apr 2.
     
  2. Regulatory landscape of enhancer-mediated transcriptional activation
    Kawasaki K, #Fukaya T.
    Trends in Cell Biology, 13 February, 2024. doi:10.1016/j.tcb.2024.01.008
    紹介記事
     
  3. Retrotransposon renaissance in early embryos. 
    Guo Y, Li TD, #Modzelewski AJ, #Siomi H.
    Trends Genet. 2024 Jan;40(1):39-51. doi: 10.1016/j.tig.2023.10.010. Epub 2023 Nov 8.

 

  1.  The potential of the common marmoset as a model animal in ophthalmology research
    Erika Sasaki
    Global Excellence Center for Gene and Cell Therapy Symposium, Seoul National University, 22-23.3.2024
  1. 令和6年度 科学技術分野の文部科学大臣表彰 科学技術賞(研究部門)
    大日向康秀 2024.04.17
  2. good presentation award(第1回AMED-SCARDA「ワクチン開発のための世界トップレベル研究開発拠点の形成事業」合同シンポジウム)
    江森 千紘 2024.2
  1.  精子は放出するたび「フレッシュ」ではない 世界中で「精子劣化」の現実 父の加齢が子に及ぼす影響 
    篠原 隆司
    Yahoo!ニュース 2024.03.11
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    篠原 隆司
    日経新聞 2024.03.01
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    伊川 正人
    熊本日日新聞 2024.02.27
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    伊川 正人
    MONOist医療技術ニュース 2024.01.25
  5. 東大、精巣・精巣上体の老化が精子や受精卵の発育に及ぼす悪影響を発見
    伊川 正人
    日経新聞 2024.01.05